A genome-scale CRISPR screen reveals factors regulating Wnt-dependent renewal of mouse gastric epithelial cells

An ability to safely harness the powerful regenerative potential of adult stem cells for clinical applications is critically dependent on a comprehensive understanding of the underlying mechanisms regulating their activity. Epithelial organoid cultures accurately recapitulate many features of in viv...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Murakami, Kazuhiro, Terakado, Yumi, Saito, Kikue, Jomen, Yoshie, Takeda, Haruna, Oshima, Masanobu, Barker, Nick
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2021
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7848749/
https://ncbi.nlm.nih.gov/pubmed/33479180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2016806118
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