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Context-dependent activation of Wnt signaling by tumor suppressor RUNX3 in gastric cancer cells
RUNX3 is a tumor suppressor for a variety of cancers. RUNX3 suppresses the canonical Wnt signaling pathway by binding to the TCF4/β-catenin complex, resulting in the inhibition of binding of the complex to the Wnt target gene promoter. Here, we confirmed that RUNX3 suppressed Wnt signaling activity...
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| Publicado no: | Cancer Sci |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Publishing Ltd
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4317806/ https://ncbi.nlm.nih.gov/pubmed/24447505 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.12356 |
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