Isoform-selective decrease of glycogen synthase kinase-3-beta (GSK-3β) reduces synaptic tau phosphorylation, transcellular spreading, and aggregation

It has been suggested that aberrant activation of glycogen synthase kinase-3-beta (GSK-3β) can trigger abnormal tau hyperphosphorylation and aggregation, which ultimately leads to neuronal/synaptic damage and impaired cognition in Alzheimer disease (AD). We examined if isoform-selective partial redu...

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Publicado no:iScience
Main Authors: Amaral, Ana Claudia, Perez-Nievas, Beatriz G., Siao Tick Chong, Michael, Gonzalez-Martinez, Alicia, Argente-Escrig, Herminia, Rubio-Guerra, Sara, Commins, Caitlin, Muftu, Serra, Eftekharzadeh, Bahareh, Hudry, Eloise, Fan, Zhanyun, Ramanan, Prianca, Takeda, Shuko, Frosch, Matthew P., Wegmann, Susanne, Gomez-Isla, Teresa
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7848608/
https://ncbi.nlm.nih.gov/pubmed/33554064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2021.102058
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