Single nucleotide variants lead to dysregulation of the human mitochondrial NAD(P)(+)-dependent malic enzyme

Human mitochondrial NAD(P)(+)-dependent malic enzyme (ME2) is well recognized to associate with cancer cell metabolism, and the single nucleotide variants (SNVs) of ME2 may play a role in enzyme regulation. Here we reported that the SNVs of ME2 occurring in the allosteric sites lead to inactivation...

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Publicado no:iScience
Main Authors: Hsieh, Ju-Yi, Yang, Hao-Ping, Tewary, Sunil Kumar, Cheng, Hui-Chen, Liu, Yi-Liang, Tai, Shih-Chieh, Chen, Wei-Lin, Hsu, Chien-Hui, Huang, Ting-Jhen, Chou, Chuan-Jung, Huang, Yu-Nan, Peng, Ching-Tien, Ho, Meng-Chiao, Liu, Guang-Yaw, Hung, Hui-Chih
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7847962/
https://ncbi.nlm.nih.gov/pubmed/33554057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2021.102034
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