Head-to-head study of oxelumab and adalimumab in a mouse model of ulcerative colitis based on NOD/Scid IL2Rγ(null) mice reconstituted with human peripheral blood mononuclear cells

This study's aim was to demonstrate that the combination of patient immune profiling and testing in a humanized mouse model of ulcerative colitis (UC) might lead to patient stratification for treatment with oxelumab. First, immunological profiles of UC patients and non-UC donors were analyzed f...

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Detalhes bibliográficos
Publicado no:Dis Model Mech
Main Authors: Jodeleit, Henrika, Winkelmann, Paula, Caesar, Janina, Sterz, Sebastian, Holdt, Lesca M., Beigel, Florian, Stallhofer, Johannes, Breiteneicher, Simone, Bartnik, Eckart, Leeuw, Thomas, Siebeck, Matthias, Gropp, Roswitha
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7847261/
https://ncbi.nlm.nih.gov/pubmed/33293281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.046995
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