The Combination of Patient Profiling and Preclinical Studies in a Mouse Model Based on NOD/Scid IL2Rγ (null) Mice Reconstituted With Peripheral Blood Mononuclear Cells From Patients With Ulcerative Colitis May Lead to Stratification of Patients for Treatment With Adalimumab

BACKGROUND: To date, responsiveness to tumor necrosis factor alpha inhibitors in ulcerative colitis (UC) patients is not predictable. This is partially due to a lack of understanding of the underlying inflammatory processes. The aim of this study was to identify immunological subgroups of patients w...

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Detalhes bibliográficos
Publicado no:Inflamm Bowel Dis
Main Authors: Jodeleit, Henrika, Caesar, Janina, Villarroel Aguilera, Christina, Sterz, Sebastian, Holdt, Lesca, Beigel, Florian, Stallhofer, Johannes, Breiteneicher, Simone, Bartnik, Eckart, Siebeck, Matthias, Gropp, Roswitha
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Basic Science Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7054775/
https://ncbi.nlm.nih.gov/pubmed/31782956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ibd/izz284
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