PARP-1 and SIRT-1 are Interacted in Diabetic Nephropathy by Activating AMPK/PGC-1α Signaling Pathway

INTRODUCTION: Diabetic nephropathy (DN) is a metabolic disorder characterized by the accumulation of extracellular matrix (ECM). This study aims to investigate whether exists an interplay between poly (ADP-ribose) polymerase 1 (PARP-1) and sirtuin 1 (SIRT-1) in DN via AMP-activated protein kinase (A...

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Vydáno v:Diabetes Metab Syndr Obes
Hlavní autoři: Zhu, Hengmei, Fang, Zhi, Chen, Jiehui, Yang, Yun, Gan, Jiacheng, Luo, Liang, Zhan, Xiaojiang
Médium: Artigo
Jazyk:Inglês
Vydáno: Dove 2021
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7846827/
https://ncbi.nlm.nih.gov/pubmed/33531822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DMSO.S291314
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