FANCD2 modulates the mitochondrial stress response to prevent common fragile site instability

Common fragile sites (CFSs) are genomic regions frequently involved in cancer-associated rearrangements. Most CFSs lie within large genes, and their instability involves transcription- and replication-dependent mechanisms. Here, we uncover a role for the mitochondrial stress response pathway in the...

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Udgivet i:Commun Biol
Main Authors: Fernandes, Philippe, Miotto, Benoit, Saint-Ruf, Claude, Said, Maha, Barra, Viviana, Nähse, Viola, Ravera, Silvia, Cappelli, Enrico, Naim, Valeria
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7846573/
https://ncbi.nlm.nih.gov/pubmed/33514811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-021-01647-8
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