A carregar...
Tdp1 protects from topoisomerase 1–mediated chromosomal breaks in adult zebrafish but is dispensable during larval development
Deficiency in the DNA end-processing enzyme, tyrosyl-DNA phosphodiesterase 1 (TDP1), causes progressive neurodegeneration in humans. Here, we generated a tdp1 knockout zebrafish and confirmed the lack of TDP1 activity. In adulthood, homozygotes exhibit hypersensitivity to topoisomerase 1 (Top1) pois...
Na minha lista:
| Publicado no: | Sci Adv |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Association for the Advancement of Science
2021
|
| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7846158/ https://ncbi.nlm.nih.gov/pubmed/33514542 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abc4165 |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|