Tdp1 protects from topoisomerase 1–mediated chromosomal breaks in adult zebrafish but is dispensable during larval development

Deficiency in the DNA end-processing enzyme, tyrosyl-DNA phosphodiesterase 1 (TDP1), causes progressive neurodegeneration in humans. Here, we generated a tdp1 knockout zebrafish and confirmed the lack of TDP1 activity. In adulthood, homozygotes exhibit hypersensitivity to topoisomerase 1 (Top1) pois...

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Udgivet i:Sci Adv
Main Authors: Zaksauskaite, Ringaile, Thomas, Ruth C, van Eeden, Freek, El-Khamisy, Sherif F.
Format: Artigo
Sprog:Inglês
Udgivet: American Association for the Advancement of Science 2021
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7846158/
https://ncbi.nlm.nih.gov/pubmed/33514542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abc4165
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