TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo

Defective Tyrosyl-DNA phosphodiesterase 1 (TDP1) can cause spinocerebellar ataxia with axonal neuropathy (SCAN1), a neurodegenerative syndrome associated with marked cerebellar atrophy and peripheral neuropathy. Although SCAN1 lymphoblastoid cells show pronounced defects in the repair of chromosomal...

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Detaylı Bibliyografya
Asıl Yazarlar: Katyal, Sachin, El-Khamisy, Sherif F, Russell, Helen R, Li, Yang, Ju, Limei, Caldecott, Keith W, McKinnon, Peter J
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2007
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2080805/
https://ncbi.nlm.nih.gov/pubmed/17914460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601869
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