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SUMO modification of the neuroprotective protein TDP1 facilitates chromosomal single-strand break repair
Breaking and sealing one strand of DNA is an inherent feature of chromosome metabolism to overcome torsional barriers. Failure to reseal broken DNA strands results in protein-linked DNA breaks, causing neurodegeneration in humans. This is typified by defects in tyrosyl DNA phosphodiesterase 1 (TDP1)...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Pub. Group
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3316882/ https://ncbi.nlm.nih.gov/pubmed/22415824 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms1739 |
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