TDP1 deficiency sensitizes human cells to base damage via distinct topoisomerase I and PARP mechanisms with potential applications for cancer therapy

Por Alagoz, Meryem, Wells, Owen S., El-Khamisy, Sherif F.
Publicado em 2014

SUMO modification of the neuroprotective protein TDP1 facilitates chromosomal single-strand break repair

Por Hudson, Jessica J.R., Chiang, Shih-Chieh, Wells, Owen S., Rookyard, Chris, El-Khamisy, Sherif F.
Publicado em 2012

Specialized interfaces of Smc5/6 control hinge stability and DNA association

Por Alt, Aaron, Dang, Hung Q., Wells, Owen S., Polo, Luis M., Smith, Matt A., McGregor, Grant A., Welte, Thomas, Lehmann, Alan R., Pearl, Laurence H., Murray, Johanne M., Oliver, Antony W.
Publicado no Nat Commun (2017)

Destabilized SMC5/6 complex leads to chromosome breakage syndrome with severe lung disease

Por van der Crabben, Saskia N., Hennus, Marije P., McGregor, Grant A., Ritter, Deborah I., Nagamani, Sandesh C.S., Wells, Owen S., Harakalova, Magdalena, Chinn, Ivan K., Alt, Aaron, Vondrova, Lucie, Hochstenbach, Ron, van Montfrans, Joris M., Terheggen-Lagro, Suzanne W., van Lieshout, Stef, van Roosmalen, Markus J., Renkens, Ivo, Duran, Karen, Nijman, Isaac J., Kloosterman, Wigard P., Hennekam, Eric, Orange, Jordan S., van Hasselt, Peter M., Wheeler, David A., Palecek, Jan J., Lehmann, Alan R., Oliver, Antony W., Pearl, Laurence H., Plon, Sharon E., Murray, Johanne M., van Haaften, Gijs
Publicado no J Clin Invest (2016)