تحميل...
TDP1 deficiency sensitizes human cells to base damage via distinct topoisomerase I and PARP mechanisms with potential applications for cancer therapy
Base damage and topoisomerase I (Top1)-linked DNA breaks are abundant forms of endogenous DNA breakage, contributing to hereditary ataxia and underlying the cytotoxicity of a wide range of anti-cancer agents. Despite their frequency, the overlapping mechanisms that repair these forms of DNA breakage...
محفوظ في:
| المؤلفون الرئيسيون: | , , |
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| التنسيق: | Artigo |
| اللغة: | Inglês |
| منشور في: |
Oxford University Press
2014
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| الوصول للمادة أونلاين: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3950670/ https://ncbi.nlm.nih.gov/pubmed/24335147 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt1260 |
| الوسوم: |
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