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TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo
Defective Tyrosyl-DNA phosphodiesterase 1 (TDP1) can cause spinocerebellar ataxia with axonal neuropathy (SCAN1), a neurodegenerative syndrome associated with marked cerebellar atrophy and peripheral neuropathy. Although SCAN1 lymphoblastoid cells show pronounced defects in the repair of chromosomal...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group
2007
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2080805/ https://ncbi.nlm.nih.gov/pubmed/17914460 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601869 |
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