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Hydroxychloroquine-mediated inhibition of SARS-CoV-2 entry is attenuated by TMPRSS2

Hydroxychloroquine, used to treat malaria and some autoimmune disorders, potently inhibits viral infection of SARS coronavirus (SARS-CoV-1) and SARS-CoV-2 in cell-culture studies. However, human clinical trials of hydroxychloroquine failed to establish its usefulness as treatment for COVID-19. This...

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Podrobná bibliografie
Vydáno v:PLoS Pathog
Hlavní autoři: Ou, Tianling, Mou, Huihui, Zhang, Lizhou, Ojha, Amrita, Choe, Hyeryun, Farzan, Michael
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2021
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7845965/
https://ncbi.nlm.nih.gov/pubmed/33465165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1009212
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