Inhibition of SARS-CoV-2 by Highly Potent Broad-Spectrum Anti-Coronaviral Tylophorine-Based Derivatives

Tylophorine-based compounds and natural cardiotonic steroids (cardenolides and bufadienolides) are two classes of transmissible gastroenteritis coronavirus inhibitors, targeting viral RNA and host cell factors, respectively. We tested both types of compounds against two types of coronaviruses, to co...

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Bibliografski detalji
Izdano u:Front Pharmacol
Glavni autori: Yang, Cheng-Wei, Lee, Yue-Zhi, Hsu, Hsing-Yu, Jan, Jia-Tsrong, Lin, Yi-Ling, Chang, Sui-Yuan, Peng, Tzu-Ting, Yang, Ruey-Bing, Liang, Jian-Jong, Liao, Chun-Che, Chao, Tai-Ling, Pang, Yu-Hau, Kao, Han-Chieh, Huang, Wen-Zheng, Lin, Jiunn-Horng, Chang, Chun-Ping, Niu, Guang-Hao, Wu, Szu-Huei, Sytwu, Huey-Kang, Chen, Chiung-Tong, Lee, Shiow-Ju
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2020
Teme:
Pharmacology
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7845692/
https://ncbi.nlm.nih.gov/pubmed/33519469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.606097
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