Inhibition of SARS-CoV-2 by Highly Potent Broad-Spectrum Anti-Coronaviral Tylophorine-Based Derivatives

Tylophorine-based compounds and natural cardiotonic steroids (cardenolides and bufadienolides) are two classes of transmissible gastroenteritis coronavirus inhibitors, targeting viral RNA and host cell factors, respectively. We tested both types of compounds against two types of coronaviruses, to co...

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Bibliografische gegevens
Gepubliceerd in:Front Pharmacol
Hoofdauteurs: Yang, Cheng-Wei, Lee, Yue-Zhi, Hsu, Hsing-Yu, Jan, Jia-Tsrong, Lin, Yi-Ling, Chang, Sui-Yuan, Peng, Tzu-Ting, Yang, Ruey-Bing, Liang, Jian-Jong, Liao, Chun-Che, Chao, Tai-Ling, Pang, Yu-Hau, Kao, Han-Chieh, Huang, Wen-Zheng, Lin, Jiunn-Horng, Chang, Chun-Ping, Niu, Guang-Hao, Wu, Szu-Huei, Sytwu, Huey-Kang, Chen, Chiung-Tong, Lee, Shiow-Ju
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2020
Onderwerpen:
Pharmacology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7845692/
https://ncbi.nlm.nih.gov/pubmed/33519469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.606097
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