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Natural cardenolides suppress coronaviral replication by downregulating JAK1 via a Na(+)/K(+)-ATPase independent proteolysis

An unprecedented biological function of natural cardenolides independent of their membrane target Na(+)/K(+)-ATPase is disclosed. Previously, we reported that cardenolides impart anti-transmissible gastroenteritis coronavirus (anti-TGEV) activity through the targeting of Na(+)/K(+)-ATPase and its as...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Biochem Pharmacol
Prif Awduron: Yang, Cheng-Wei, Hsu, Hsing-Yu, Chang, Hsin-Yu, Lee, Yue-Zhi, Lee, Shiow-Ju
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Elsevier Inc. 2020
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7314687/
https://ncbi.nlm.nih.gov/pubmed/32592721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2020.114122
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