Inhibition of SARS-CoV-2 by Highly Potent Broad-Spectrum Anti-Coronaviral Tylophorine-Based Derivatives

Tylophorine-based compounds and natural cardiotonic steroids (cardenolides and bufadienolides) are two classes of transmissible gastroenteritis coronavirus inhibitors, targeting viral RNA and host cell factors, respectively. We tested both types of compounds against two types of coronaviruses, to co...

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Publicado en:Front Pharmacol
Autores principales: Yang, Cheng-Wei, Lee, Yue-Zhi, Hsu, Hsing-Yu, Jan, Jia-Tsrong, Lin, Yi-Ling, Chang, Sui-Yuan, Peng, Tzu-Ting, Yang, Ruey-Bing, Liang, Jian-Jong, Liao, Chun-Che, Chao, Tai-Ling, Pang, Yu-Hau, Kao, Han-Chieh, Huang, Wen-Zheng, Lin, Jiunn-Horng, Chang, Chun-Ping, Niu, Guang-Hao, Wu, Szu-Huei, Sytwu, Huey-Kang, Chen, Chiung-Tong, Lee, Shiow-Ju
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7845692/
https://ncbi.nlm.nih.gov/pubmed/33519469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.606097
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