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Stereorandomization as a Method to Probe Peptide Bioactivity

[Image: see text] Solid-phase peptide synthesis (SPPS) is usually performed with optically pure building blocks to prepare peptides as single enantiomers. Herein we report that SPPS using racemic amino acids provides stereorandomized (sr) peptides, containing up to billions of different stereoisomer...

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Detalhes bibliográficos
Publicado no:ACS Cent Sci
Main Authors: Siriwardena, Thissa N., Gan, Bee-Ha, Köhler, Thilo, van Delden, Christian, Javor, Sacha, Reymond, Jean-Louis
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2021
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7845017/
https://ncbi.nlm.nih.gov/pubmed/33532575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscentsci.0c01135
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