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Th17 Cells Require Ongoing Classic IL-6 Receptor Signaling to Retain Transcriptional and Functional Identity

Acting in concert with TGF-β, IL-6 signaling induces Th17 cell development by programming Th17-related genes via STAT3. A role for IL-6 signaling beyond the inductive phase of Th17 cell development has not been defined, as IL-23 signaling downstream of Th17 cell induction also activates STAT3 and is...

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Bibliografski detalji
Izdano u:Sci Immunol
Glavni autori: Harbour, Stacey N., DiToro, Daniel F., Witte, Steven J., Zindl, Carlene L., Gao, Min, Schoeb, Trenton R., Jones, Gareth W., Jones, Simon A., Hatton, Robin D., Weaver, Casey T.
Format: Artigo
Jezik:Inglês
Izdano: 2020
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7843024/
https://ncbi.nlm.nih.gov/pubmed/32680955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.aaw2262
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