Expression of the of the androgen receptor governs radiation resistance in a subset of glioblastomas vulnerable to anti-androgen therapy

New approaches are needed to overcome intrinsic therapy resistance in glioblastoma (GBM). Because GBMs exhibit sexual dimorphism and are reported to express steroid hormone receptors, we reasoned that signaling through the androgen receptor (AR) could mediate therapy resistance in GBM, much as it do...

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Pubblicato in:Mol Cancer Ther
Autori principali: Werner, Christian K., Nna, Uchechi J., Sun, Hanshi, Wilder-Romans, Kari, Dresser, Joseph, Kothari, Ayesha U., Zhou, Weihua, Yao, Yangyang, Rao, Arvind, Stallard, Stefanie, Koschmann, Carl, Bor, Tarik, Debinski, Waldemar, Hegedus, Alexander M., Morgan, Meredith A., Venneti, Sriram, Baskin-Bey, Edwina, Spratt, Daniel E., Colman, Howard, Sarkaria, Jann N., Chinnaiyan, Arul M., Eisner, Joel R., Speers, Corey, Lawrence, Theodore S., Strowd, Roy E., Wahl, Daniel R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7842184/
https://ncbi.nlm.nih.gov/pubmed/32796101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-20-0095
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