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Subtraction-free and bisulfite-free specific sequencing of 5-methylcytosine and its oxidized derivatives at base resolution

Although various methods have been developed for sequencing cytosine modifications, it is still challenging for specific and quantitative sequencing of individual modification at base-resolution. For example, to obtain both true 5-methylcytosine (5mC) and true 5-hydroxymethylcytosine (5hmC) informat...

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Vydáno v:Nat Commun
Hlavní autoři: Liu, Yibin, Hu, Zhiyuan, Cheng, Jingfei, Siejka-Zielińska, Paulina, Chen, Jinfeng, Inoue, Masato, Ahmed, Ahmed Ashour, Song, Chun-Xiao
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7840749/
https://ncbi.nlm.nih.gov/pubmed/33504799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-20920-2
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