Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism

Neurotensin receptor 1 (NTSR1) and related G protein–coupled receptors of the ghrelin family are clinically unexploited, and several mechanistic aspects of their activation and inactivation have remained unclear. Enabled by a new crystallization design, we present five new structures: apo-state NTSR...

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Vydáno v:Sci Adv
Hlavní autoři: Deluigi, Mattia, Klipp, Alexander, Klenk, Christoph, Merklinger, Lisa, Eberle, Stefanie A., Morstein, Lena, Heine, Philipp, Mittl, Peer R. E., Ernst, Patrick, Kamenecka, Theodore M., He, Yuanjun, Vacca, Santiago, Egloff, Pascal, Honegger, Annemarie, Plückthun, Andreas
Médium: Artigo
Jazyk:Inglês
Vydáno: American Association for the Advancement of Science 2021
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7840143/
https://ncbi.nlm.nih.gov/pubmed/33571132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abe5504
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