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Structure of signaling-competent neurotensin receptor 1 obtained by directed evolution in Escherichia coli
Crystallography has advanced our understanding of G protein–coupled receptors, but low expression levels and instability in solution have limited structural insights to very few selected members of this large protein family. Using neurotensin receptor 1 (NTR1) as a proof of principle, we show that t...
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| Главные авторы: | , , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3926081/ https://ncbi.nlm.nih.gov/pubmed/24453215 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1317903111 |
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