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Comprehensive analysis of heterotrimeric G-protein complex diversity and their interactions with GPCRs in solution

Agonist binding to G-protein–coupled receptors (GPCRs) triggers signal transduction cascades involving heterotrimeric G proteins as key players. A major obstacle for drug design is the limited knowledge of conformational changes upon agonist binding, the details of interaction with the different G p...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Hillenbrand, Matthias, Schori, Christian, Schöppe, Jendrik, Plückthun, Andreas
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4371982/
https://ncbi.nlm.nih.gov/pubmed/25733868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1417573112
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