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Comprehensive analysis of heterotrimeric G-protein complex diversity and their interactions with GPCRs in solution
Agonist binding to G-protein–coupled receptors (GPCRs) triggers signal transduction cascades involving heterotrimeric G proteins as key players. A major obstacle for drug design is the limited knowledge of conformational changes upon agonist binding, the details of interaction with the different G p...
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| Publicado en: | Proc Natl Acad Sci U S A |
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| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
2015
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4371982/ https://ncbi.nlm.nih.gov/pubmed/25733868 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1417573112 |
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