Structure of signaling-competent neurotensin receptor 1 obtained by directed evolution in Escherichia coli

Crystallography has advanced our understanding of G protein–coupled receptors, but low expression levels and instability in solution have limited structural insights to very few selected members of this large protein family. Using neurotensin receptor 1 (NTR1) as a proof of principle, we show that t...

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Bibliographic Details
Main Authors: Egloff, Pascal, Hillenbrand, Matthias, Klenk, Christoph, Batyuk, Alexander, Heine, Philipp, Balada, Stefanie, Schlinkmann, Karola M., Scott, Daniel J., Schütz, Marco, Plückthun, Andreas
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2014
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PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3926081/
https://ncbi.nlm.nih.gov/pubmed/24453215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1317903111
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