Rigid fusions of designed helical repeat binding proteins efficiently protect a binding surface from crystal contacts

Designed armadillo repeat proteins (dArmRPs) bind extended peptides in a modular way. The consensus version recognises alternating arginines and lysines, with one dipeptide per repeat. For generating new binding specificities, the rapid and robust analysis by crystallography is key. Yet, we have pre...

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Foilsithe in:Sci Rep
Main Authors: Ernst, Patrick, Honegger, Annemarie, van der Valk, Floor, Ewald, Christina, Mittl, Peer R. E., Plückthun, Andreas
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group UK 2019
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6838082/
https://ncbi.nlm.nih.gov/pubmed/31700118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-52121-9
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