A synthetic mechanogenetic gene circuit for autonomous drug delivery in engineered tissues

Mechanobiologic signals regulate cellular responses under physiologic and pathologic conditions. Using synthetic biology and tissue engineering, we developed a mechanically responsive bioartificial tissue that responds to mechanical loading to produce a preprogrammed therapeutic biologic drug. By de...

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Bibliografski detalji
Izdano u:Sci Adv
Glavni autori: Nims, Robert J., Pferdehirt, Lara, Ho, Noelani B., Savadipour, Alireza, Lorentz, Jeremiah, Sohi, Sima, Kassab, Jordan, Ross, Alison K., O’Conor, Christopher J., Liedtke, Wolfgang B., Zhang, Bo, McNulty, Amy L., Guilak, Farshid
Format: Artigo
Jezik:Inglês
Izdano: American Association for the Advancement of Science 2021
Teme:
Research Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7840132/
https://ncbi.nlm.nih.gov/pubmed/33571125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abd9858
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