A synthetic mechanogenetic gene circuit for autonomous drug delivery in engineered tissues

Mechanobiologic signals regulate cellular responses under physiologic and pathologic conditions. Using synthetic biology and tissue engineering, we developed a mechanically responsive bioartificial tissue that responds to mechanical loading to produce a preprogrammed therapeutic biologic drug. By de...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Nims, Robert J., Pferdehirt, Lara, Ho, Noelani B., Savadipour, Alireza, Lorentz, Jeremiah, Sohi, Sima, Kassab, Jordan, Ross, Alison K., O’Conor, Christopher J., Liedtke, Wolfgang B., Zhang, Bo, McNulty, Amy L., Guilak, Farshid
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2021
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7840132/
https://ncbi.nlm.nih.gov/pubmed/33571125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abd9858
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