A synthetic mechanogenetic gene circuit for autonomous drug delivery in engineered tissues

Mechanobiologic signals regulate cellular responses under physiologic and pathologic conditions. Using synthetic biology and tissue engineering, we developed a mechanically responsive bioartificial tissue that responds to mechanical loading to produce a preprogrammed therapeutic biologic drug. By de...

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Dades bibliogràfiques
Publicat a:Sci Adv
Autors principals: Nims, Robert J., Pferdehirt, Lara, Ho, Noelani B., Savadipour, Alireza, Lorentz, Jeremiah, Sohi, Sima, Kassab, Jordan, Ross, Alison K., O’Conor, Christopher J., Liedtke, Wolfgang B., Zhang, Bo, McNulty, Amy L., Guilak, Farshid
Format: Artigo
Idioma:Inglês
Publicat: American Association for the Advancement of Science 2021
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7840132/
https://ncbi.nlm.nih.gov/pubmed/33571125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abd9858
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