A synthetic mechanogenetic gene circuit for autonomous drug delivery in engineered tissues

Mechanobiologic signals regulate cellular responses under physiologic and pathologic conditions. Using synthetic biology and tissue engineering, we developed a mechanically responsive bioartificial tissue that responds to mechanical loading to produce a preprogrammed therapeutic biologic drug. By de...

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Vydáno v:Sci Adv
Hlavní autoři: Nims, Robert J., Pferdehirt, Lara, Ho, Noelani B., Savadipour, Alireza, Lorentz, Jeremiah, Sohi, Sima, Kassab, Jordan, Ross, Alison K., O’Conor, Christopher J., Liedtke, Wolfgang B., Zhang, Bo, McNulty, Amy L., Guilak, Farshid
Médium: Artigo
Jazyk:Inglês
Vydáno: American Association for the Advancement of Science 2021
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7840132/
https://ncbi.nlm.nih.gov/pubmed/33571125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abd9858
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