MUC1-C integrates activation of the IFN-γ pathway with suppression of the tumor immune microenvironment in triple-negative breast cancer

BACKGROUND: Immune checkpoint inhibitors (ICIs) have had a profound impact on the treatment of many tumors; however, their effectiveness against triple-negative breast cancers (TNBCs) has been limited. One factor limiting responsiveness of TNBCs to ICIs is a lack of functional tumor-infiltrating lym...

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Detalhes bibliográficos
Publicado no:J Immunother Cancer
Main Authors: Yamashita, Nami, Long, Mark, Fushimi, Atsushi, Yamamoto, Masaaki, Hata, Tsuyoshi, Hagiwara, Masayuki, Bhattacharya, Atrayee, Hu, Qiang, Wong, Kwok-Kin, Liu, Song, Kufe, Donald
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2021
Assuntos:
Clinical/Translational Cancer Immunotherapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7839859/
https://ncbi.nlm.nih.gov/pubmed/33495298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-002115
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