Targeted Ptpn11 deletion in mice reveals the essential role of SHP2 in osteoblast differentiation and skeletal homeostasis

The maturation and function of osteoblasts (OBs) rely heavily on the reversible phosphorylation of signaling proteins. To date, most of the work in OBs has focused on phosphorylation by tyrosyl kinases, but little has been revealed about dephosphorylation by protein tyrosine phosphatases (PTPases)....

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Detalhes bibliográficos
Publicado no:Bone Res
Main Authors: Wang, Lijun, Yang, Huiliang, Huang, Jiahui, Pei, Shaopeng, Wang, Liyun, Feng, Jian Q., Jing, Dian, Zhao, Hu, Kronenberg, Henry M., Moore, Douglas C., Yang, Wentian
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7838289/
https://ncbi.nlm.nih.gov/pubmed/33500396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41413-020-00129-7
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