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Epigenetic modulation of FBW7/Mcl-1 pathway for lung cancer therapy
Methylation induces epigenetic silencing of tumor suppressor genes in human lung cancer. Inhibition of DNA methyltransferases by decitabine (DAC) can demethylate and activate epigenetically silenced tumor suppressor genes. Epigenetic therapy using DAC should be an attractive strategy for lung cancer...
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| Publicado no: | Cancer Biol Ther |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7833779/ https://ncbi.nlm.nih.gov/pubmed/33336620 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2020.1856756 |
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