Proteomic screen reveals Fbw7 as a modulator of the NF-κB pathway

Fbw7 is a ubiquitin-ligase that targets several oncoproteins for proteolysis, but the full range of Fbw7 substrates is not known. Here we show that by performing quantitative proteomics combined with degron motif searches, we effectively screened for a more complete set of Fbw7 targets. We identify...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Arabi, Azadeh, Ullah, Karim, Branca, Rui M.M., Johansson, Johan, Bandarra, Daniel, Haneklaus, Moritz, Fu, Jing, Ariës, Ingrid, Nilsson, Peter, Den Boer, Monique L., Pokrovskaja, Katja, Grandér, Dan, Xiao, Gutian, Rocha, Sonia, Lehtiö, Janne, Sangfelt, Olle
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4354031/
https://ncbi.nlm.nih.gov/pubmed/22864569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms1975
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