Proteomic screen reveals Fbw7 as a modulator of the NF-κB pathway

Fbw7 is a ubiquitin-ligase that targets several oncoproteins for proteolysis, but the full range of Fbw7 substrates is not known. Here we show that by performing quantitative proteomics combined with degron motif searches, we effectively screened for a more complete set of Fbw7 targets. We identify...

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Bibliografski detalji
Izdano u:Nat Commun
Glavni autori: Arabi, Azadeh, Ullah, Karim, Branca, Rui M.M., Johansson, Johan, Bandarra, Daniel, Haneklaus, Moritz, Fu, Jing, Ariës, Ingrid, Nilsson, Peter, Den Boer, Monique L., Pokrovskaja, Katja, Grandér, Dan, Xiao, Gutian, Rocha, Sonia, Lehtiö, Janne, Sangfelt, Olle
Format: Artigo
Jezik:Inglês
Izdano: Nature Pub. Group 2012
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4354031/
https://ncbi.nlm.nih.gov/pubmed/22864569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms1975
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