Proteomic screen reveals Fbw7 as a modulator of the NF-κB pathway

Fbw7 is a ubiquitin-ligase that targets several oncoproteins for proteolysis, but the full range of Fbw7 substrates is not known. Here we show that by performing quantitative proteomics combined with degron motif searches, we effectively screened for a more complete set of Fbw7 targets. We identify...

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Detaylı Bibliyografya
Yayımlandı:Nat Commun
Asıl Yazarlar: Arabi, Azadeh, Ullah, Karim, Branca, Rui M.M., Johansson, Johan, Bandarra, Daniel, Haneklaus, Moritz, Fu, Jing, Ariës, Ingrid, Nilsson, Peter, Den Boer, Monique L., Pokrovskaja, Katja, Grandér, Dan, Xiao, Gutian, Rocha, Sonia, Lehtiö, Janne, Sangfelt, Olle
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Pub. Group 2012
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4354031/
https://ncbi.nlm.nih.gov/pubmed/22864569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms1975
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