Heterogeneous Escape from X Chromosome Inactivation Results in Sex Differences in Type I IFN Responses at the Single Human pDC Level

Immune responses differ between women and men, and type I interferon (IFN) responses following Toll-like receptor 7 (TLR7) stimulation are higher in women. The precise mechanisms driving these sex differences in immunity are unknown. To investigate possible genetic factors, we quantify escape from X...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Rep
Prif Awduron: Hagen, Sven Hendrik, Henseling, Florian, Hennesen, Jana, Savel, Hélène, Delahaye, Solenne, Richert, Laura, Ziegler, Susanne Maria, Altfeld, Marcus
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Authors. 2020
Pynciau:
Report
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7833293/
https://ncbi.nlm.nih.gov/pubmed/33296655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.108485
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