Heterogeneous Escape from X Chromosome Inactivation Results in Sex Differences in Type I IFN Responses at the Single Human pDC Level

Immune responses differ between women and men, and type I interferon (IFN) responses following Toll-like receptor 7 (TLR7) stimulation are higher in women. The precise mechanisms driving these sex differences in immunity are unknown. To investigate possible genetic factors, we quantify escape from X...

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Udgivet i:Cell Rep
Main Authors: Hagen, Sven Hendrik, Henseling, Florian, Hennesen, Jana, Savel, Hélène, Delahaye, Solenne, Richert, Laura, Ziegler, Susanne Maria, Altfeld, Marcus
Format: Artigo
Sprog:Inglês
Udgivet: The Authors. 2020
Fag:
Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7833293/
https://ncbi.nlm.nih.gov/pubmed/33296655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.108485
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