HIV turns plasmacytoid dendritic cells (pDC) into TRAIL-expressing killer pDC and down-regulates HIV coreceptors by Toll-like receptor 7-induced IFN-α

Plasmacytoid dendritic cells (pDC) are key players in viral immunity and produce IFN-α after HIV-1 exposure, which in turn regulates TNF-related apoptosis-inducing ligand (TRAIL) expression by CD4(+) T cells. We show here that infectious and noninfectious HIV-1 virions induce activation of pDC into...

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Hlavní autoři: Hardy, Andrew W., Graham, David R., Shearer, Gene M., Herbeuval, Jean-Philippe
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2007
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2077277/
https://ncbi.nlm.nih.gov/pubmed/17956986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0707244104
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