T-cell responses to sequentially emerging viral escape mutants shape long-term HIV-1 population dynamics

HIV-1 strains harboring immune escape mutations can persist in circulation, but the impact of selection by multiple HLA alleles on population HIV-1 dynamics remains unclear. In Japan, HIV-1 Reverse Transcriptase codon 135 (RT135) is under strong immune pressure by HLA-B*51:01-restricted and HLA-B*52...

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Vydáno v:PLoS Pathog
Hlavní autoři: Akahoshi, Tomohiro, Gatanaga, Hiroyuki, Kuse, Nozomi, Chikata, Takayuki, Koyanagi, Madoka, Ishizuka, Naoki, Brumme, Chanson J., Murakoshi, Hayato, Brumme, Zabrina L., Oka, Shinichi, Takiguchi, Masafumi
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2020
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7833229/
https://ncbi.nlm.nih.gov/pubmed/33370400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1009177
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