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Discovery of new acetylcholinesterase inhibitors for Alzheimer’s disease: virtual screening and in vitro characterisation

For more than two decades, the development of potent acetylcholinesterase (AChE) inhibitors has been an ongoing task to treat dementia associated with Alzheimer’s disease and improve the pharmacokinetic properties of existing drugs. In the present study, we used three docking-based virtual screening...

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Dettagli Bibliografici
Pubblicato in:J Enzyme Inhib Med Chem
Autori principali: David, Benoit, Schneider, Pascal, Schäfer, Philipp, Pietruszka, Jörg, Gohlke, Holger
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2021
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7833026/
https://ncbi.nlm.nih.gov/pubmed/33478277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2021.1876685
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