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Discovery of new acetylcholinesterase inhibitors for Alzheimer’s disease: virtual screening and in vitro characterisation

For more than two decades, the development of potent acetylcholinesterase (AChE) inhibitors has been an ongoing task to treat dementia associated with Alzheimer’s disease and improve the pharmacokinetic properties of existing drugs. In the present study, we used three docking-based virtual screening...

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Detalhes bibliográficos
Publicado no:J Enzyme Inhib Med Chem
Main Authors: David, Benoit, Schneider, Pascal, Schäfer, Philipp, Pietruszka, Jörg, Gohlke, Holger
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7833026/
https://ncbi.nlm.nih.gov/pubmed/33478277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2021.1876685
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