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Probing the Binding Requirements of Modified Nucleosides with the DNA Nuclease SNM1A

SNM1A is a nuclease that is implicated in DNA interstrand crosslink repair and, as such, its inhibition is of interest for overcoming resistance to chemotherapeutic crosslinking agents. However, the number and identity of the metal ion(s) in the active site of SNM1A are still unconfirmed, and only a...

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Pubblicato in:Molecules
Autori principali: Dürr, Eva-Maria, McGouran, Joanna F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2021
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7827217/
https://ncbi.nlm.nih.gov/pubmed/33435514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules26020320
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