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A hydroxamic-acid-containing nucleoside inhibits DNA repair nuclease SNM1A
Nine modified nucleosides, incorporating zinc-binding pharmacophores, have been synthesised and evaluated as inhibitors of the DNA repair nuclease SNM1A. The series included oxyamides, hydroxamic acids, hydroxamates, a hydrazide, a squarate ester and a squaramide. A hydroxamic acid-derived nucleosid...
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| Publicado no: | Org Biomol Chem |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Royal Society of Chemistry
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6984127/ https://ncbi.nlm.nih.gov/pubmed/31380542 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9ob01133a |
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