Squaramide‐Based 5’‐Phosphate Replacements Bind to the DNA Repair Exonuclease SNM1A

Phosphate groups are often crucial to biological activity and interactions of oligonucleotides, but confer poor membrane permeability. In addition, the group's lability to enzymatic hydrolysis is an obstacle to its use in therapeutics and in biological tools. We present the synthesis of N‐oxyam...

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Gepubliceerd in:ChemistrySelect
Hoofdauteurs: Dürr, Eva‐Maria, Doherty, William, Lee, Sook Y., El‐Sagheer, Afaf H., Shivalingam, Arun, McHugh, Peter J., Brown, Tom, McGouran, Joanna F.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2018
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6685075/
https://ncbi.nlm.nih.gov/pubmed/31414040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/slct.201803375
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