SUMOylation mediates CtIP’s functions in DNA end resection and replication fork protection

Double-strand breaks and stalled replication forks are a significant threat to genomic stability that can lead to chromosomal rearrangements or cell death. The protein CtIP promotes DNA end resection, an early step in homologous recombination repair, and has been found to protect perturbed forks fro...

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Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Locke, Andrew J, Hossain, Lazina, McCrostie, Glynnis, Ronato, Daryl A, Fitieh, Amira, Rafique, Tanzeem Ahmed, Mashayekhi, Fatemeh, Motamedi, Mobina, Masson, Jean-Yves, Ismail, Ismail Hassan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2021
Schlagworte:
Genome Integrity, Repair and Replication
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7826263/
https://ncbi.nlm.nih.gov/pubmed/33406258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa1232
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