Thioredoxin-1 maintains mitochondrial function via mechanistic target of rapamycin signalling in the heart

AIMS: Thioredoxin 1 (Trx1) is an evolutionarily conserved oxidoreductase that cleaves disulphide bonds in oxidized substrate proteins such as mechanistic target of rapamycin (mTOR) and maintains nuclear-encoded mitochondrial gene expression. The cardioprotective effect of Trx1 has been demonstrated...

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Detalhes bibliográficos
Publicado no:Cardiovasc Res
Main Authors: Oka, Shin-Ichi, Chin, Adave, Park, Ji Yeon, Ikeda, Shohei, Mizushima, Wataru, Ralda, Guersom, Zhai, Peiyong, Tong, Mingming, Byun, Jaemin, Tang, Fan, Einaga, Yudai, Huang, Chun-Yang, Kashihara, Toshihide, Zhao, Mengyuan, Nah, Jihoon, Tian, Bin, Hirabayashi, Yoko, Yodoi, Junji, Sadoshima, Junichi
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7825501/
https://ncbi.nlm.nih.gov/pubmed/31584633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvz251
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