Thioredoxin-1 maintains mechanistic target of rapamycin (mTOR) function during oxidative stress in cardiomyocytes

Thioredoxin 1 (Trx1) is a 12-kDa oxidoreductase that catalyzes thiol-disulfide exchange reactions to reduce proteins with disulfide bonds. As such, Trx1 helps protect the heart against stresses, such as ischemia and pressure overload. Mechanistic target of rapamycin (mTOR) is a serine/threonine kina...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Oka, Shin-ichi, Hirata, Tsuyoshi, Suzuki, Wataru, Naito, Daichi, Chen, Yanbin, Chin, Adave, Yaginuma, Hiroaki, Saito, Toshiro, Nagarajan, Narayani, Zhai, Peiyong, Bhat, Santosh, Schesing, Kevin, Shao, Dan, Hirabayashi, Yoko, Yodoi, Junji, Sciarretta, Sebastiano, Sadoshima, Junichi
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2017
Schlagworte:
Cell Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5704480/
https://ncbi.nlm.nih.gov/pubmed/28939765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.807735
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