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Design, Synthesis and In Vitro Investigation of Novel Basic Celastrol Carboxamides as Bio-Inspired Leishmanicidal Agents Endowed with Inhibitory Activity against Leishmania Hsp90

The natural triterpene celastrol (CE) is here used as lead compound for the design and synthesis of a panel of eleven CE carboxamides that were tested in vitro for their growth inhibitory activity against Leishmania infantum and L. tropica parasites. Among them, in vitro screening identified four ba...

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Détails bibliographiques
Publié dans:Biomolecules
Auteurs principaux: Bassanini, Ivan, Parapini, Silvia, Ferrandi, Erica E., Gabriele, Elena, Basilico, Nicoletta, Taramelli, Donatella, Sparatore, Anna
Format: Artigo
Langue:Inglês
Publié: MDPI 2021
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7824787/
https://ncbi.nlm.nih.gov/pubmed/33466300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom11010056
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